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Mpox Virus and its ocular surface manifestations.
Nikhil Chakravarty1, Darshi Hemani2, Ramya Paravastu3
1Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA; School of Medicine, California University of Science and Medicine, Colton, CA, USA.
The Ocular Surface
|July 7, 2024
Summary
Mpox virus (MPXV) Clade IIb causes severe ocular disease. This review details MPXV
Area of Science:
- Virology
- Epidemiology
- Ophthalmology
Background:
- Mpox virus (MPXV) causes Mpox disease, a smallpox-like illness.
- Clade IIb MPXV strains rapidly spread globally in 2022, causing severe symptoms.
- Ocular complications are common in Mpox, but Clade IIb trends are emerging.
Purpose of the Study:
- To review the viral and genomic structures of MPXV.
- To examine the epidemiology and pathology of systemic and ocular Mpox.
- To discuss potential prophylactic and therapeutic interventions for Mpox.
Main Methods:
- Literature review of MPXV, Mpox disease, and ocular manifestations.
- Analysis of viral and genomic structures.
- Epidemiological and pathological data synthesis.
Main Results:
- MPXV causes significant ocular surface complications.
- Clade IIb MPXV shows enhanced transmissibility and severity.
- All MPXV strains can infect ocular tissues.
Conclusions:
- Urgent need to understand MPXV mechanisms causing ocular anomalies.
- Emerging global incidence of ocular Mpox by Clade IIb requires attention.
- Further research into prophylaxis and therapeutics is crucial.
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