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Updated: Jun 21, 2025
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Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
Published on: July 1, 2013
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An elastomer with in situ generated pure zwitterionic surfaces for fibrosis-resistant implants
Xianchi Zhou1, Wenzhong Cao1, Yongcheng Chen1
1MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310058, Zhejiang Province, PR China.
Acta Biomaterialia
|July 7, 2024
Summary
A new zwitterionic elastomer coating-free surface prevents foreign body response (FBR) and fibrotic capsule formation. This biomaterial enhances implant longevity and performance, offering a promising solution for biomedical devices.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Immunology
Background:
- Polymeric elastomers are crucial for implantable biomedical devices.
- Foreign body response (FBR) and fibrotic capsule formation limit implant effectiveness.
- Developing effective anti-FBR coatings for elastomers is challenging.
Purpose of the Study:
- To develop a coating-free elastomer with superior immunocompatibility.
- To create an in situ generated zwitterionic layer for enhanced anti-fouling properties.
- To evaluate the elastomer's performance in reducing FBR and improving implant longevity.
Main Methods:
- A zwitterionic monomer derivative was used to create a coating-free elastomer.
- An in situ chemical trigger generated a super-hydrophilic zwitterionic surface layer.
- Subcutaneous implantation in rodents was performed to assess inflammatory and fibrotic responses.
- Continuous subcutaneous insulin infusion (CSII) catheters were fabricated and tested.
Main Results:
- The zwitterionic elastomer surface effectively repelled protein adsorption, cell adhesion, and platelet activation.
- Negligible inflammatory responses were observed after 2 weeks of implantation in rodents.
- No significant fibrotic capsule formation was detected after 6 months of subcutaneous implantation.
- CSII catheters made from the elastomer showed prolonged longevity and performance compared to commercial devices.
Conclusions:
- The developed coating-free elastomer exhibits excellent immunocompatibility and anti-fouling properties.
- The in situ generated zwitterionic layer significantly mitigates foreign body response and fibrotic encapsulation.
- This novel elastomer holds great potential for improving the performance and lifespan of various implantable biomedical devices.
