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Related Experiment Video

Updated: May 2, 2026

A Mobile Outside-in Technique of Transforaminal Lumbar Endoscopy for Lumbar Disc Herniations
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Transperineal Is the Way To Go.

Adrian Pilatz1, Fabian Stangl2, Jennifer Kranz3

  • 1Department of Urology, Pediatric Urology and Andrology, Justus Liebig University Giessen, Giessen, Germany.

European Urology Focus
|July 7, 2024
PubMed
Summary

Transperineal prostate biopsy offers superior safety over transrectal biopsy, significantly reducing infectious complications. Guidelines now recommend transperineal biopsy as the preferred initial choice for patients.

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Area of Science:

  • Urology
  • Medical Procedures
  • Infectious Disease Prevention

Background:

  • Prostate biopsy is a critical diagnostic tool for prostate cancer.
  • Traditional transrectal prostate biopsy is associated with infectious complications.
  • Minimally invasive techniques are being explored to improve patient safety.

Purpose of the Study:

  • To compare the infectious complication rates between transperineal and transrectal prostate biopsy.
  • To evaluate the efficacy and safety of transperineal prostate biopsy.
  • To inform clinical practice guidelines regarding prostate biopsy techniques.

Main Methods:

  • Systematic review and meta-analysis of available evidence.
  • Comparison of infectious complication rates (e.g., sepsis, urinary tract infections) between biopsy methods.
  • Analysis of patient outcomes and adverse events.

Main Results:

  • Transperineal prostate biopsy demonstrated significantly lower rates of infectious complications compared to transrectal biopsy.
  • No significant difference in diagnostic yield was observed between the two methods.
  • Transperineal biopsy is associated with a favorable safety profile.

Conclusions:

  • Transperineal prostate biopsy is the preferred method due to its superior safety profile regarding infectious complications.
  • The European Association of Urology guidelines recommend transperineal biopsy as the first choice.
  • Adoption of transperineal biopsy can enhance patient safety and reduce healthcare burdens associated with infections.