Nigrostriatal lesions enhance striatal 3H-apomorphine and 3H-spiroperidol binding

Following unilateral 6-hydroxydopamine nigrostriatal lesions in rats, the binding of both 3H-apomorphine and 3H-spiroperidol in the striatum is increased. In rats with incomplete lesions or at early time points after lesion, binding is not significantly different from control levels.