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Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
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Related Experiment Video

Updated: Jun 21, 2025

Application of Lucilia sericata Larvae in Debridement of Pressure Wounds in Outpatient Settings
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A Highly Stable, Multifunctional Janus Dressing for Treating Infected Wounds.

Jixia Deng1, Miao Hu2, Zhuyun Cai3

  • 1Shanghai Frontiers Science Center of Advanced Textiles, College of Textiles, Donghua University, Shanghai, 201620, China.

Advanced Healthcare Materials
|July 8, 2024
PubMed
Summary

A novel Janus dressing made from poly(lactide caprolactone) (PLCL) effectively absorbs wound exudate unidirectionally. This advanced wound dressing promotes healing in infected wounds by reducing inflammation and bacterial load.

Keywords:
Janus structureexudate managementinfected wound healingmultifunctionalwound dressing

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Wound Healing

Background:

  • Excessive exudate and infection impede chronic wound healing.
  • Current wound dressings often lack stability and multifunctional capabilities.

Purpose of the Study:

  • To develop a stable, multifunctional Janus dressing with unidirectional exudate transfer.
  • To evaluate its efficacy in promoting the healing of infected wounds.

Main Methods:

  • Fabrication of a Janus dressing from poly(lactide caprolactone) (PLCL) using acid hydrolysis for tunable hydrophilicity.
  • Incorporation of phenol red and epigallocatechin gallate for detection, antibacterial, antioxidant, and anti-inflammatory properties.
  • In vivo assessment using a methicillin-resistant Staphylococcus aureus-infected wound model.

Main Results:

  • The Janus dressing demonstrated excellent unidirectional liquid transfer and structural stability.
  • In vivo studies showed accelerated epithelialization, collagen deposition, reduced inflammation, and high angiogenesis.
  • Achieved an ideal wound closure rate of 98.4% by day 14 in infected wounds.

Conclusions:

  • The developed Janus dressing offers a promising strategy for chronic wound treatment.
  • Its multifunctionality, including exudate management and antibacterial properties, addresses key challenges in wound healing.
  • Simple fabrication and inherent stability make it suitable for clinical translation.