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Updated: Jun 21, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

931

Phytochemicals targeting ferroptosis in cardiovascular diseases: Recent advances and therapeutic perspectives

Jianxia Wen1, Lu Li1, Yi Yang1

  • 1School of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Chongqing Key Laboratory of Sichuan Chongqing Joint Construction of Specialty Food, Xihua University, Chengdu, China.

Phytotherapy Research : PTR
|July 8, 2024
PubMed

Insights

Ferroptosis, an iron-dependent cell death, is crucial in cardiovascular diseases. Phytochemicals targeting ferroptosis show promise for new cardioprotective therapies and treatments.

Area of Science:

  • Biochemistry
  • Cardiology
  • Pharmacology

Background:

  • Ferroptosis, a regulated cell death pathway dependent on iron, is implicated in cardiovascular disease pathogenesis.
  • Cardiovascular conditions like heart failure and myocardial infarction are linked to ferroptosis.
  • Phytochemicals are emerging as potential therapeutic agents targeting ferroptosis for cardiovascular protection.

Purpose of the Study:

  • To provide an overview of ferroptosis initiation and regulation.
  • To explore ferroptosis regulatory factors as therapeutic targets for cardiovascular diseases.
  • To summarize phytochemicals' effects on ferroptosis and their clinical potential in cardiovascular treatment.

Main Methods:

  • Literature review on ferroptosis mechanisms.
  • Analysis of studies on ferroptosis in cardiovascular disease models.
  • Systematic summary of phytochemicals targeting ferroptosis.

Main Results:

  • Ferroptosis significantly influences the progression of various cardiovascular diseases.
  • Core ferroptosis regulators present potential therapeutic targets.
  • Phytochemicals demonstrate cardioprotective effects by modulating ferroptosis.

Conclusions:

  • Understanding ferroptosis mechanisms is key for developing novel cardiovascular therapies.
  • Phytochemicals offer a promising avenue for treating cardiovascular diseases via ferroptosis modulation.
  • Further research into phytochemical mechanisms can accelerate clinical applications.

Keywords:
cardiovascular diseasesferroptosismyocardial ischemia/reperfusion injuryphytochemicalspotential mechanisms

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