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Causal relationships between psychological disorders and functional gastrointestinal disorders: a bidirectional
Tangyi Liu1, Zeyu Wang, Xiaoyu Kang
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.
Depression is a causal risk factor for functional dyspepsia, constipation, and irritable bowel syndrome (IBS). A bidirectional causal link was also found between IBS and anxiety or depression.
Area of Science:
- Psychiatry and Gastroenterology
- Genetic Epidemiology
- Mendelian Randomization
Background:
- Observational studies suggest bidirectional links between psychological disorders and functional gastrointestinal disorders (FGIDs).
- The causal nature of these associations remains uncertain.
- This study employs a bidirectional two-sample Mendelian randomization approach.
Purpose of the Study:
- To investigate the causal relationship between common psychological disorders (depression, anxiety) and functional gastrointestinal disorders (FGIDs).
- To determine if psychological disorders are risk factors for FGIDs, and vice versa.
Main Methods:
- Utilized genome-wide association study (GWAS) summary statistics for depression, anxiety, functional dyspepsia, constipation, and irritable bowel syndrome (IBS).
- Employed a bidirectional two-sample Mendelian randomization analysis.
- The primary analytical method was the inverse variance weighted (IVW) approach.
Main Results:
- Genetically predicted depression significantly increased the risk of functional dyspepsia, constipation, and IBS.
- Genetically predicted anxiety was associated with an increased risk of IBS.
- Genetically predicted IBS was associated with increased risks of both depression and anxiety.
Conclusions:
- Depression is identified as a causal risk factor for three common FGIDs.
- A bidirectional causal relationship exists between IBS and both anxiety and depression.
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