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Updated: Jun 21, 2025
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Chemical Analysis of Water-accommodated Fractions of Crude Oil Spills Using TIMS-FT-ICR MS
Published on: March 3, 2017
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A Gated TIMS FTICR MS Instrument to Decipher Isomeric Content of Complex Organic Mixtures
Christopher A Wootton1, Julien Maillard2,3, Alina Theisen1
1Bruker Daltonics GmbH & Co. Kg, 28359 Bremen, Germany.
Analytical Chemistry
|July 8, 2024
Summary
This study introduces a new analytical instrument combining Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS) with gated trapped ion mobility spectrometry (gTIMS). This innovation enhances the analysis of complex mixtures, revealing isomeric diversity and molecular distributions with greater chemical insight.
Area of Science:
- Analytical Chemistry
- Physical Chemistry
- Spectrometry
Background:
- Modern research requires advanced analytical techniques for complex materials.
- Ultrahigh resolution mass spectrometry (MS), especially FTICR MS, offers deep chemical insight but limited structural information.
- There is a need for analytical strategies that provide deeper levels of chemical insight into complex samples.
Purpose of the Study:
- To present the first implementation and results of an FTICR MS with fully integrated dual accumulation analysis and gated trapped ion mobility spectrometry (gTIMS) capability.
- To demonstrate the instrument's ability to analyze complex mixtures with extended charge capacity and parallel accumulation.
- To showcase the potential of this integrated system to significantly advance the analysis of complex mixtures.
Main Methods:
- Integration of gated trapped ion mobility spectrometry (gTIMS) with Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS).
- Utilized dual accumulation analysis with FTICR MS for high dynamic range acquisition.
- Benchmarking with Suwannee River fulvic acid (SRFA) and application to bio-oil samples.
Main Results:
- Achieved a high dynamic range of 4 orders of magnitude within a single FTICR acquisition.
- Retained a linear relationship between TIMS elution voltage and reduced mobility over a wide range.
- Successfully separated and assigned charge state distributions in SRFA and distinguished isomeric diversity in bio-oils.
Conclusions:
- The integrated gTIMS with FTICR MS provides enhanced isomeric and molecular distribution insights for complex mixtures.
- This analytical approach maintains high resolving power and mass accuracy, enabling rapid extraction of valuable molecular data.
- The development promises transformative effects in fields like energy transition, environmental studies, and biological research.
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