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Related Experiment Video

Updated: Jun 21, 2025

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Published on: May 17, 2021

Advanced biomedical and electronic dual-function skin patch created through microfluidic-regulated 3D bioprinting.

Ting Dong¹, Jie Hu², Yue Dong¹

¹State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Jiangsu Key Laboratory of Fine Chemicals and Functional Polymer Materials, Nanjing Tech University, Nanjing, 210009, China.

Bioactive Materials

|July 8, 2024

Summary

Researchers developed a dual-function artificial skin patch using 3D bioprinting. This innovative material promotes wound healing and mimics natural skin

Keywords:

3D bioprinting Pressure sensor Skin patches Wound healing

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Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Published on: September 2, 2015

Related Experiment Videos

Last Updated: Jun 21, 2025

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Published on: May 17, 2021

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Published on: September 2, 2015

Area of Science:

Multidisciplinary research integrating materials science, biology, medicine, and tissue engineering for advanced artificial skin.
Development of multifunctional, intelligent, and regenerative skin substitutes.

Background:

Existing artificial skin research focuses on multifunctionality and tissue regeneration.
Need for advanced materials that combine biomedical properties with electronic sensing capabilities.

Purpose of the Study:

To create a dual-function skin patch with both biomedical and electronic capabilities.
To enhance wound healing, promote tissue repair, and mimic natural skin's sensory functions.

Main Methods:

Utilized a specialized 3D printing ink: polyurethane and bioactive glass (PU-BG).
Employed microfluidic-regulated 3D bioprinting (MRBP) for precise microstructure control and enhanced strength.
Constructed an asymmetric tri-layer structure promoting cell attachment and growth via hydrogen bonds and a hydrophilic gradient.

Main Results:

The dual-function skin patch demonstrated enhanced hemostasis, antibacterial properties, and stimulated blood vessel regeneration.
Accelerated wound healing process observed in vivo.
Achieved sensitive electronic skin (e-skin) functionality with high sensitivity (5.87 kPa⁻¹), cyclic stability (>500 cycles), wide detection range (0-150 kPa), and high pressure resolution (0.1%).

Conclusions:

The developed PU-BG skin patch offers a versatile and effective solution for dual-function applications.
Presents significant implications for clinical applications in wound healing and tissue repair.
Provides new insights into the integration of biomedical and electronic functionalities in artificial skin.