The Regulation of Pyroptosis and Ferroptosis by MicroRNAs in Cardiovascular Diseases

Area of Science:

• Biomedical science
• Molecular biology
• Cardiology

Background:

• Cardiovascular diseases (CVDs) are the leading global cause of death.
• MicroRNAs (miRNAs) are key regulators of cellular processes, including metabolism, homeostasis, and programmed cell death (PCD).
• Pyroptosis and ferroptosis are critical non-apoptotic PCD types implicated in heart failure pathogenesis.

Purpose of the Study:

• To review the intricate relationship between miRNAs and pyroptosis and ferroptosis in the context of CVDs.
• To explore how miRNAs modulate these specific PCD pathways in cardiovascular disease.
• To identify potential therapeutic targets within miRNA-regulated PCD pathways for CVD treatment.

Main Methods:

• Comprehensive literature review of studies investigating miRNAs, pyroptosis, ferroptosis, and CVDs.
• Analysis of existing research on the regulatory roles of miRNAs in non-apoptotic cell death.
• Synthesis of findings to elucidate the crosstalk between miRNAs and PCD in cardiovascular pathogenesis.

Main Results:

• Evidence indicates that various miRNAs can regulate both pyroptosis and ferroptosis.
• These miRNA-mediated regulatory actions influence the progression and inhibition of CVDs.
• The interplay between miRNAs and these PCDs is a significant factor in heart failure development.

Conclusions:

• The crosstalk between miRNAs and pyroptosis/ferroptosis pathways is crucial in CVDs.
• Targeting these miRNA-regulated PCD pathways presents a promising avenue for novel therapeutic interventions.
• Further research is warranted to validate these pathways as effective therapeutic strategies against cardiovascular diseases.