Albumin-to-Globulin Ratio Combined with Neutrophil-to-Lymphocyte Ratio as a Prognostic Predictor in Multiple Myeloma with Renal Impairment
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View abstract on PubMed
Summary
This summary is machine-generated.The albumin-to-globulin ratio (AGR) and neutrophil-to-lymphocyte ratio (NLR), combined as ANS, show prognostic value in multiple myeloma with renal impairment. High ANS predicts worse survival, aiding risk assessment.
Area Of Science
- Hematology
- Oncology
- Biomarkers
Background
- The albumin-to-globulin ratio (AGR) and neutrophil-to-lymphocyte ratio (NLR) are emerging prognostic indicators in cancer.
- Their combined prognostic value in multiple myeloma (MM) with renal impairment (RI) remains under investigation.
Purpose Of The Study
- To evaluate the prognostic significance of the combined albumin-to-globulin ratio and neutrophil-to-lymphocyte ratio (ANS) in patients with MM and RI.
- To develop a predictive model for overall survival (OS) and progression-free survival (PFS).
Main Methods
- Retrospective analysis of 79 MM patients with RI from 2011-2018.
- Receiver operating curves (ROCs) determined optimal AGR and NLR thresholds.
- Cox regression, Kaplan-Meier analysis, and nomogram construction assessed prognostic values.
Main Results
- Optimal cut-offs: AGR 1.57, NLR 2.27.
- High ANS and high NLR correlated with worse OS and PFS.
- Multivariate analysis confirmed NLR and ANS as independent predictors for OS and PFS; low AGR predicted reduced OS.
- Nomograms accurately predicted OS (c-index: 0.785) and PFS (c-index: 0.786).
Conclusions
- The combined ANS score is a potential prognostic biomarker for MM patients with RI.
- Proposed nomograms can aid in prognostic predictions for this patient group.
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