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Related Experiment Videos

Hypothesis: bromocriptine lacks intrinsic dopamine receptor stimulating properties.

D M Jackson, O F Jenkins

    Journal of Neural Transmission
    |January 1, 1985
    PubMed
    Summary

    Bromocriptine (BRC) does not cause behavioral stimulation alone in rodents. However, BRC enhances the stimulant effects of dopamine receptor agonists like apomorphine and dopamine (DA) in mice and rats.

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    Area of Science:

    • Neuropharmacology
    • Behavioral Neuroscience

    Background:

    • Bromocriptine (BRC) is a dopamine receptor agonist.
    • Rodent models are used to study drug effects on behavior.

    Purpose of the Study:

    • To investigate the behavioral effects of Bromocriptine (BRC) in rodents.
    • To determine if BRC can cause locomotor stimulation or stereotyped behavior.
    • To explore the interaction of BRC with other dopamine receptor agonists.

    Main Methods:

    • Administered BRC to reserpine plus alpha-methyl-p-tyrosine (AMPT) pretreated mice and rats.
    • Tested BRC in combination with L-DOPA, apomorphine, d-amphetamine, and nomifensine.
    • Applied BRC and dopamine (DA) directly to rat brain nuclei (nucleus accumbens, caudate nucleus).

    Main Results:

    • BRC alone did not produce locomotor stimulation or stereotypy in rodents.
    • BRC potentiated the stimulant effects of apomorphine and d-amphetamine.
    • BRC enhanced the stimulant effect of DA when co-applied to the nucleus accumbens.
    • BRC was inactive when applied alone to rat brain nuclei.

    Conclusions:

    • BRC does not induce behavioral excitation independently in rodents.
    • BRC requires the presence of other dopamine receptor agonists to elicit stimulant effects.
    • BRC may modulate the signal transmission downstream of dopamine receptors.

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