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Echovirus meningomyeloencephalitis with administration of intrathecal immunoglobulin

M G Hadfield, M Seidlin, S A Houff

    Journal of Neuropathology and Experimental Neurology
    |September 1, 1985
    PubMed

    Insights

    Echovirus meningomyeloencephalitis caused severe neuronal loss in the CNS, leading to ataxia and polio-like symptoms. Intraventricular immunoglobulin therapy showed limited effectiveness against the virus and associated lesions.

    Area of Science:

    • Neurology
    • Virology
    • Immunology

    Background:

    • Echovirus infections can cause severe central nervous system (CNS) inflammation, including meningomyeloencephalitis.
    • Neuronal damage, particularly in the cerebellum and spinal cord, is a hallmark of severe echovirus CNS disease.
    • Ataxia and poliomyelitis-like syndromes are common clinical manifestations.

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