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Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...

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PROGNOSTIC VALUES OF NEUTROPHIL/LYMPHOCYTE RATIO IN SEVERE BURN PATIENTS.

T D Hung1, N N Lam1,2, N T Hung1

  • 1Le Huu Trac National Burn Hospital, Viet Nam.

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|July 8, 2024
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The neutrophil-to-lymphocyte ratio (NLR) can predict mortality in severe burn patients. Elevated NLR levels on day 7 post-burn indicate a higher risk of death, aiding in prognosis.

Keywords:
NLRoutcomesevere burns

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Area of Science:

  • Biomedical Science
  • Inflammation Research
  • Trauma Care

Background:

  • Severe burns trigger a systemic inflammatory response.
  • The neutrophil-to-lymphocyte ratio (NLR) is a marker of inflammation.
  • Prognostic indicators for severe burn outcomes are crucial.

Purpose of the Study:

  • To assess the characteristics of NLR in severe burn patients.
  • To determine the prognostic value of NLR for mortality.
  • To identify NLR's role in predicting outcomes after severe burns.

Main Methods:

  • Retrospective analysis of 245 severe burn patients (≥20% TBSA).
  • Exclusion of patients with comorbidities or combined injuries.
  • Collection of NLR on admission, day 3, and day 7 post-burn, along with patient data and outcomes.

Main Results:

  • NLR levels were elevated above normal at all measured time points.
  • Mortality group showed significantly higher NLR on admission, day 3, and day 7 compared to survivors (p < .01).
  • Day 7 NLR was an independent predictor of mortality (p < .05), with an AUC of 0.85.

Conclusions:

  • Neutrophil-to-lymphocyte ratio on day 7 post-burn is a significant predictor of mortality in severe burn patients.
  • NLR, alongside age, burn extent, and inhalation injury, aids in mortality risk assessment.
  • This ratio offers a valuable tool for early identification of high-risk burn patients.