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THE EFFECT OF MULTIDRUG-RESISTANT ORGANISM INFECTION ON MORTALITY OF BURN PATIENTS AT RSUPN DR. CIPTO MANGUNKUSUMO

R M Veronica1, E J Nelwan1, J Kumalawati1

  • 1University of Indonesia / RS dr. Cipto Mangunkusumo, Jakarta, Indonesia.

Annals of Burns and Fire Disasters
|July 8, 2024
PubMed

Insights

Multidrug-resistant organism (MDRO) infections significantly increase mortality in burn patients, with length of stay and age being key contributing factors. Understanding these risks is crucial for improving patient outcomes.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Burn Surgery

Background:

  • Burn patients face high risks of infection due to compromised skin barriers and increased antibiotic resistance.
  • Multidrug-resistant organisms (MDROs) are a growing concern, potentially leading to sepsis, increased morbidity, and mortality in this vulnerable population.

Purpose of the Study:

  • To investigate the impact of multidrug-resistant organism (MDRO) infections on mortality rates in burn patients.
  • To identify factors influencing mortality in burn patients with MDRO infections.

Main Methods:

  • A retrospective cohort study analyzed medical records of 160 burn patients from January 2020 to June 2022.
  • Data included patient demographics, burn characteristics, medical device use, length of stay, and causative pathogens.
  • Bivariate and multivariate analyses were performed to assess the effect of MDRO infection and associated variables on mortality.

Main Results:

  • The most common Gram-negative MDRO pathogens were *K. pneumoniae* (29.91%), *Enterobacter sp* (22.32%), and *Acinetobacter* (20.54%).
  • Mortality was significantly higher in patients with MDRO infections (45%) compared to those without (21.43%).
  • Multivariate analysis identified length of stay and age as significant predictors of mortality in burn patients with MDRO infections.

Conclusions:

  • MDRO infections are a critical determinant of mortality in burn patients.
  • Longer length of stay and older age are associated with increased mortality risk in burn patients with MDRO infections.
  • Targeted interventions addressing these factors may help reduce mortality in this patient group.
Keywords:
MDROburnmortality

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