Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lidocaine Versus Amiodarone in Patients With Shockable Out-of-Hospital Cardiac Arrest: A Target Trial Emulation.

Critical care medicine·2026
Same author

Targeted Degradation of NETs in Lupus with DNASE1L3 Deficiency.

The New England journal of medicine·2026
Same author

Recombinant human diamine oxidase prevents histamine-induced hypoxia, shock and death in guinea pigs.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2026
Same author

Critical evaluation of the key mediators causing life-threatening symptoms during human anaphylaxis.

Drug discovery today·2026
Same author

Endovascular thrombectomy with or without intravenous thrombolysis in large-vessel ischemic stroke: an updated meta-analysis.

Scientific reports·2026
Same author

Effects of an early restrictive versus liberal fluid strategy on long-term patient-centered outcomes in sepsis-induced hypotension: an open-label, randomized controlled trial.

American journal of respiratory and critical care medicine·2026

Related Experiment Video

Updated: May 11, 2026

High Throughput Sequential ELISA for Validation of Biomarkers of Acute Graft-Versus-Host Disease
09:00

High Throughput Sequential ELISA for Validation of Biomarkers of Acute Graft-Versus-Host Disease

Published on: October 31, 2012

15.8K

Thromboelastography in acute immunologic reactions: a prospective pilot study.

Calvin Lukas Kienbacher1, Christian Schoergenhofer2, Gerhard Ruzicka1

  • 1Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria.

Research and Practice in Thrombosis and Haemostasis
|July 8, 2024
PubMed
Summary

Maximum lysis (ML) measured by thromboelastography correlates with the severity of acute immunologic reactions. Elevated ML and hyperfibrinolysis indicate more severe allergic reactions and angioedema.

Keywords:
blood coagulationfibrinolysisimmunological modelsthromboelastographytissue plasminogen activator

More Related Videos

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
04:32

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

Published on: June 5, 2019

7.6K
Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
06:28

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization

Published on: June 4, 2020

6.8K

Related Experiment Videos

Last Updated: May 11, 2026

High Throughput Sequential ELISA for Validation of Biomarkers of Acute Graft-Versus-Host Disease
09:00

High Throughput Sequential ELISA for Validation of Biomarkers of Acute Graft-Versus-Host Disease

Published on: October 31, 2012

15.8K
A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
04:32

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

Published on: June 5, 2019

7.6K
Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
06:28

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization

Published on: June 4, 2020

6.8K

Area of Science:

  • Immunology
  • Hematology
  • Emergency Medicine

Background:

  • Biomarkers of fibrinolysis are elevated in acute immunologic reactions like allergic reactions and angioedema.
  • The direct association between fibrinolysis and disease severity remains unclear.

Purpose of the Study:

  • To investigate the association between maximum lysis (ML), a measure of fibrinolysis, and the severity of acute immunologic reactions.
  • To determine if ML, measured by thromboelastography, can predict disease severity in patients presenting with acute immunologic reactions.

Main Methods:

  • Patients with acute immunologic reactions were recruited, and their clinical severity was graded.
  • Maximum lysis (ML%) was determined using thromboelastography (EXTEM and APTEM tests) upon admission.
  • Exact logistic regression was used to analyze the association between ML% and disease severity, and the presence of hyperfibrinolysis.

Main Results:

  • A significant association was found between higher ML% and increased symptom severity (OR, 1.07; P = .003).
  • Hyperfibrinolysis (ML > 15%) was detected in 6 patients and strongly associated with severe symptoms (OR, 17.59; P = .02).
  • Levels of D-dimer, tryptase, and immunoglobulin E also increased with reaction severity.

Conclusions:

  • Maximum lysis (ML), as quantified by thromboelastography, is a significant biomarker associated with the severity of acute immunologic reactions.
  • Thromboelastography can aid in assessing the severity of allergic reactions and angioedema.