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Causal relationship between obesity and anorectal abscess: a Mendelian randomization study
XiaoYu Zeng1, HanYu Wang1, Yang Deng2
1Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Frontiers in Medicine
|July 8, 2024
Summary
Obesity is a significant risk factor for anorectal abscess (ARB). This study confirms a causal link, suggesting weight management can reduce ARB incidence.
Area of Science:
- Genetics
- Public Health
- Gastroenterology
Background:
- Observational studies suggest obesity is a risk factor for anorectal abscess (ARB).
- A definitive causal genetic link between obesity and ARB has not been established.
Purpose of the Study:
- To investigate the potential causal genetic relationship between obesity and anorectal abscess (ARB).
Main Methods:
- Utilized Mendelian randomization (MR) analysis with genome-wide association study (GWAS) data from European ancestry.
- Employed inverse variance weighted (IVW) as the primary analysis method, supported by weighted median and Bayesian model averaging.
Main Results:
- Confirmed a positive causal effect of body mass index (BMI) on ARB risk (OR 1.974).
- Obesity-related traits like body fat percentage and waist circumference showed causal associations with ARB, which were mediated by BMI.
Conclusions:
- Establishes a causal relationship between obesity and increased risk of anorectal abscess (ARB).
- Recommends weight control as a key strategy for reducing ARB incidence.
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