Related Experiment Video
Updated: Jun 21, 2025
A Modified Precipitation Method to Isolate Urinary Exosomes
Published on: January 16, 2015
Urinary exosomes: Potential diagnostic markers and application in bladder cancer
Ji Liu1,2, Zhang Zhijin1,2, Wentao Zhang1,2
1Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
Background:
The exosome is a critical component of the intercellular communication., playing a vital role in regulating cell function. These small vesicles contain proteins, mRNAs, miRNAs, and lncRNAs, surrounded by lipid bilayer substances. Most cells in the human body can produce exosomes, released into various body fluids such as urine, blood, and cerebrospinal fluid. Bladder cancer is the most common tumor in the urinary system, with high recurrence and metastasis rates. Early diagnosis and treatment are crucial for improving patient outcomes.
Methods:
This study employed the PubMed search engine to retrieve publicly accessible data pertaining to urinary exosomes.
Results:
We summarize the origins and intricate biological characteristics of urinary exosomes, the introduction of research methodologies used in basic experiments to isolate and analyze these exosomes, the discussion of their applications and progress in the diagnosis and treatment of bladder cancer, and the exploration of the current limitations associated with using urinary exosomes as molecular biomarkers for diagnosing bladder cancer.
Conclusion:
Exosomes isolated from urine may be used as molecular biomarkers for early detection of bladder cancer.
