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Related Concept Videos

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  3. Research Domains
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  11. Effects Of Multivitamin-mineral Supplementation On Chronic Stress-induced Oxidative Damage In Swiss Albino Mice.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Effects Of Multivitamin-mineral Supplementation On Chronic Stress-induced Oxidative Damage In Swiss Albino Mice.

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Effects of Multivitamin-Mineral Supplementation on Chronic Stress-Induced Oxidative Damage in Swiss Albino Mice.

Nida Suhail1, Tehreem Aftab2, Anwar Alruwaili1

  • 1Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Northern Border University, Arar, SAU.

Cureus
|July 8, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Multivitamin-mineral (MM) supplementation effectively counteracted oxidative stress induced by chronic unpredictable stress (UCS) in mice. MM treatment normalized antioxidant levels and reduced lipid peroxidation, mitigating stress-related biochemical damage.

Keywords:
antioxidantsmultivitamin-mineraloxidative damageswiss albino mice

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Toxicology

Background:

  • Stress significantly increases oxidative stress, impacting energy metabolism and contributing to disease pathophysiology.
  • Vitamins and minerals are known to modulate oxidative stress, suggesting a potential therapeutic role.

Purpose of the Study:

  • To assess the efficacy of a multivitamin-mineral (MM) supplement in mitigating oxidative stress markers.
  • To investigate the impact of MM supplementation on plasma, hepatic, and renal tissues affected by chronic stress in mice.

Main Methods:

  • Thirty male Swiss albino mice were divided into control, unpredictable chronic stress (UCS), and MM + UCS groups.
  • Mice were subjected to UCS for four weeks, followed by biochemical analysis of blood, liver, and kidney tissues.
unpredictable chronic stress
  • DNA damage in lymphocytes was assessed to corroborate biochemical findings.

    • Main Results:

    • Unpredictable chronic stress (UCS) depleted antioxidant levels (superoxide dismutase, catalase, glutathione) and increased lipid peroxidation in plasma, liver, and kidney.
    • Multivitamin-mineral (MM) supplementation reversed these detrimental effects, normalizing biochemical markers in stressed mice.
    • DNA damage analysis confirmed the protective effects of MM supplementation against stress-induced cellular damage.

    Conclusions:

    • Multivitamin-mineral (MM) supplementation demonstrates a significant capacity to alleviate oxidative stress and related biochemical disturbances.
    • These findings suggest MM supplementation could be beneficial in managing stress-induced oxidative damage in both healthy and pathological conditions.