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Cardiac safety of ribociclib evaluated with 24-hour rhythm Holter electrocardiogram

Ayse Irem Yasin1, Mahmut Uluganyan2, Zehra Sucuoglu Isleyen3

  • 1Department of Medical Oncology, Bezmialem Vakıf University, Huzur Mah. Cumhuriyet Cad., 34396, Istanbul, Turkey. ayseiremyasin@gmail.com.

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
|July 8, 2024
PubMed

Insights

Ribociclib, a breast cancer treatment, shows a low risk of early heart problems. A study using Holter ECG monitoring found no significant cardiac rhythm changes in patients after three months of treatment.

Area of Science:

  • Cardiology
  • Oncology
  • Pharmacology

Background:

  • Ribociclib is a targeted therapy used for metastatic breast cancer.
  • Assessing the cardiac safety of oncology drugs is crucial for patient management.

Purpose of the Study:

  • To evaluate the cardiac safety profile of ribociclib using 24-hour Holter electrocardiogram (ECG).
  • To determine if ribociclib treatment affects cardiac rhythm in breast cancer patients.

Main Methods:

  • The study included 42 female metastatic breast cancer patients.
  • Rhythm Holter ECGs were performed before treatment and after three months of ribociclib initiation.
  • Patients received ribociclib in combination with fulvestrant or aromatase inhibitors.

Main Results:

  • No instances of cardiotoxicity were observed in any patients.
  • Comparison of Holter ECG results before and after three months showed no statistically significant differences in cardiac rhythm.
  • The mean age of the patient cohort was 56.36 ± 12.73 years.

Conclusions:

  • This study provides the first evaluation of ribociclib's cardiac rhythm effects using Holter ECG.
  • Findings suggest that ribociclib has a low risk of causing early cardiotoxicity.
  • Ribociclib can be considered safe regarding cardiac rhythm in the early stages of treatment.
Abstract

Keywords:
CardiotoxicityHolter ECGHormon-positive breast cancerRibociclib

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