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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Aframomumlabdane, a new bislabdane diterpenoid from Aframomum arundinaceum (zingiberaceae)
Patrick Y Ango1, Arlette W Ghoda2, Destaing F Abega2
1Department of Pharmacotoxicology, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.
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A previously undescribed bislabdane diterpenoid namely aframomumlabdane (1), was isolated from the seed of Aframomum arundinaceum together with seven known compounds (2 - 8). Their structures were established based on a comprehensive analysis of HR-ESI-MS, in conjunction with their 1D and 2D-NMR data. Compound 1 was evaluated for its cytotoxic activity against four cancer cell lines: A549, HepG2, SPC212 and DLD-1. The best activity was observed against SPC212 lung cancer cell line with an IC50 value of 0.52 μM.
