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[Kidney transplantation in children].

D E Müller-Wiefel, F Schindera, B Niggemann

    Fortschritte Der Medizin
    |November 15, 1979
    PubMed
    Summary

    Pediatric renal transplantation offers improved growth and social rehabilitation for children. Despite complications like rejection and infections, long-term graft survival is achievable with specialized care.

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    Area of Science:

    • Pediatric Nephrology
    • Transplant Surgery
    • Immunology

    Background:

    • Renal transplantation is a vital treatment for end-stage renal disease in children.
    • Long-term outcomes and complications in pediatric renal transplant recipients require ongoing evaluation.

    Purpose of the Study:

    • To review a decade of experience with renal transplantation in pediatric patients.
    • To assess graft survival, patient outcomes, complications, and rehabilitation following transplantation in children.

    Main Methods:

    • Retrospective review of 40 pediatric renal transplant cases over ten years.
    • Analysis of graft survival, patient survival, complication rates, and functional outcomes.

    Main Results:

    • Mean graft survival was 19 months, with 24 children alive with functioning grafts at follow-up.

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  • Patient survival was 84% at 2 years; 7 children died, primarily from infections and cardiovascular issues.
  • Common complications included acute and chronic rejections, immunosuppressive drug side effects, hypertension, and surgical issues.

    • Conclusions:

    • Pediatric renal transplantation can lead to improved growth and full social rehabilitation.
    • Specialized pediatric centers and multidisciplinary collaboration are crucial for optimizing outcomes.
    • Management guidelines are essential to address complications and improve long-term graft and patient survival.