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Updated: Jun 21, 2025

Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy
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Elucidating the complex membrane binding of a protein with multiple anchoring domains using extHMMM

Jesper J Madsen1,2, Y Zenmei Ohkubo3

  • 1Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States of America.

Plos Computational Biology
|July 8, 2024
PubMed
Summary

Coagulation factor Va (FVa) protein binding to membranes involves domain reorganization and molecular tilt. Specific residues prefer phosphatidylserine lipids, driven mainly by electrostatic interactions, revealing complex protein-membrane dynamics.

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