Generating Utilities for the Château-Santé Base: A Novel, Generic, and Patient-Centered Health-Outcome Measure

Area of Science:

• Health Economics
• Patient-Reported Outcomes
• Psychometrics

Background:

• Developed the Château-Santé Base (CS-Base), a novel patient-centered, preference-based generic health-outcome measure.
• CS-Base utilizes a multiattribute preference response (MAPR) measurement framework.
• The need for a validated utility set for CS-Base for health-economic evaluations.

Purpose of the Study:

• To generate the first utility set for the CS-Base.
• To establish the suitability of CS-Base for health-economic evaluations.
• To derive coefficients from patient MAPR data and normalize them to a 0.0 to 1.0 utility scale.

Main Methods:

• CS-Base includes 12 health attributes, each with 4 levels.
• Derived coefficients from patient MAPR data (n=3222) and general population data from a discrete choice experiment (n=1995).
• Employed a division-value strategy to estimate the 'dead' position and normalize utility values.

Main Results:

• Analyzed data from 3222 patients and 1995 respondents.
• All MAPR coefficients were negative, logically ordered, and statistically significant.
• Utility values ranged from -0.071 to 1.0, with only 53 states deemed worse than dead (division value of -148.385).

Conclusions:

• Introduced the first CS-Base utility set using a novel 2-step derivation method.
• The method integrates societal and patient perspectives, offering advantages over traditional approaches.
• Continuous refinement of the normalization procedure and utility estimation is ongoing.