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Updated: Jun 21, 2025
Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Published on: November 27, 2019
Common definitions and variables are needed for the United States to join the conversation on acute-on-chronic liver
Jin Ge1, W Ray Kim2, Allison J Kwong2
1Division of Gastroenterology and Hepatology, Department of Medicine, University of California - San Francisco, San Francisco, California, USA.
Abstract:
Acute-on-chronic liver failure (ACLF) is a variably defined syndrome characterized by acute decompensation of cirrhosis with organ failures. At least 13 different definitions and diagnostic criteria for ACLF have been proposed, and there is increasing recognition that patients with ACLF may face disadvantages in the current United States liver allocation system. There is a need, therefore, for more standardized data collection and consensus to improve study design and outcome assessment in ACLF. In this article, we discuss the current landscape of transplantation for patients with ACLF, strategies to optimize organ utility, and data opportunities based on emerging technologies to facilitate improved data collection.
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