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Cells and Secretions of the Pancreas

Cells and Secretions of the Pancreas

The pancreas, a vital organ within the abdominal cavity, plays dual roles in the digestive and endocrine systems, collaborating with exocrine and endocrine cells to maintain optimal digestion and blood sugar levels.
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Related Experiment Video

Updated: Jun 21, 2025

Isolating and Analyzing Cells of the Pancreas Mesenchyme by Flow Cytometry

Isolating and Analyzing Cells of the Pancreas Mesenchyme by Flow Cytometry

Published on: January 28, 2017

Emerging and extensive clonal evolution in the pancreas.

Alvin P Makohon-Moore¹

¹Hackensack Meridian Health Center for Discovery and Innovation, Nutley, NJ, USA; Hackensack Meridian School of Medicine, Nutley, NJ, USA; Georgetown University Lombardi Comprehensive Cancer Center, Washington, DC, USA.

Trends in Cancer

|July 8, 2024

Summary

Pancreatic cancer precursors exist in the normal adult pancreas. These precursors develop through various pathways, offering new insights into early cancer evolution.

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Published on: June 10, 2016

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Last Updated: Jun 21, 2025

Isolating and Analyzing Cells of the Pancreas Mesenchyme by Flow Cytometry

Isolating and Analyzing Cells of the Pancreas Mesenchyme by Flow Cytometry

Published on: January 28, 2017

Efficient Differentiation of Pluripotent Stem Cells to NKX6-1+ Pancreatic Progenitors

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Published on: March 7, 2017

In Vitro Colony Assays for Characterizing Tri-potent Progenitor Cells Isolated from the Adult Murine Pancreas

In Vitro Colony Assays for Characterizing Tri-potent Progenitor Cells Isolated from the Adult Murine Pancreas

Published on: June 10, 2016

Area of Science:

Oncology
Gastroenterology
Cell Biology

Background:

Pancreatic cancer is a highly lethal malignancy with poorly understood precursor development.
Identifying and characterizing early cancer precursors is crucial for understanding disease progression.

Purpose of the Study:

To investigate the presence and origins of pancreatic cancer precursors in the normal adult pancreas.
To elucidate the diverse routes by which these precursors evolve.

Main Methods:

Utilized advanced lineage tracing and genetic analysis techniques.
Examined cellular populations within the adult pancreatic tissue.

Main Results:

Discovered hundreds to thousands of pancreatic cancer precursors within the normal adult pancreas.
Demonstrated that these precursors arise and evolve through multiple distinct developmental routes.

Conclusions:

The adult pancreas contains a significant number of potential pancreatic cancer precursors.
Understanding the heterogeneity of precursor evolution is key to developing early detection and prevention strategies for pancreatic cancer.