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Updated: Jun 21, 2025
Methods for Detecting Cough and Airway Inflammation in Mice
Published on: August 2, 2024
Patient Perception of Cough in Interstitial Lung Disease; Impact of Cough Hypersensitivity
B Hirons1,2, K Rhatigan1,2, L Wright3
1Department of Respiratory Medicine, Chest Unit, Cheyne Wing, King's College Hospital, Denmark Hill, London, SE5 9RS, UK.
Introduction:
Cough is common in interstitial lung disease (ILD) and is associated with disease progression, yet its mechanisms are understudied. We investigated cough hypersensitivity features and impact in ILD.
Methods:
Participants with ILD and cough (n = 195) completed a multiple choice and free text questionnaire on cough sensations/triggers and impacts.
Results:
The majority of participants were male (54%), aged > 65 (64%), with idiopathic pulmonary fibrosis (IPF, 75%). Common cough triggers were body position (74%), physical activity (72%), and talking (62%). Common laryngeal sensations were globus (43%), and itch/tickle (42%). Cough impacted everyday life in 55%, and all activities in 31%, causing exhaustion (59%), social embarrassment (70%), urinary incontinence (46% females), and syncope/pre-syncope (12%). The total number of cough-provoking sensations/triggers correlated with impacts; ρ = 0.73, p < 0.001.
Conclusion:
Cough hypersensitivity symptoms are prevalent in ILD and detrimentally affect quality of life. Further studies investigating mechanisms of cough hypersensitivity and targeted pharmacotherapy are warranted.
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