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Synthesis of Azo Analogs for Investigating Phosphatidic Acid-Mediated Signaling
Jawad Muayad1, Maria D Cabrera Gonzalez2,3
1Texas A & M University School of Medicine, Houston, TX, USA. jawadmuayad@tamu.edu.
Abstract:
Phosphatidic acid (PA) is a key signaling lipid that plays a crucial role in regulating various cellular processes. Studies have shown that azobenzene-containing PA analogues can be used as an all-chemical strategy for light-mediated control of PA signaling. These photoswitchable lipids offer a solution to the limitations of traditional bulk dosing methods by allowing for light- and shape-dependent interactions with protein effectors and lipid-metabolizing enzymes. This chapter describes how to synthesize AzoPA and dAzoPA.
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