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Related Concept Videos

Glucose Transporters01:27

Glucose Transporters

22.6K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
22.6K
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  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Elevated Slc3a2 Associated With Poor Prognosis And Enhanced Malignancy In Gliomas

Elevated SLC3A2 associated with poor prognosis and enhanced malignancy in gliomas

Yuheng Xu1,2, Wanqi Weng1,2, Yuhao Weng1

  • 1Department of Neurosurgery, Institute of Neuroscience, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.

Scientific Reports
|July 8, 2024

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Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
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Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

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Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
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Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

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View abstract on PubMed

Summary
This summary is machine-generated.

Solute carrier family 3 member 2 (SLC3A2) is a prognostic biomarker in gliomas, correlating with poor prognosis and influencing the tumor microenvironment. Its elevated expression impacts immune infiltration and tumor aggressiveness.

Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Cancer Genomics

Background:

  • The role of SLC3A2 (solute carrier family 3 member 2), implicated in disulfidptosis, remains uncharacterized in gliomas.
  • Gliomas are primary brain tumors with significant morbidity and mortality, necessitating novel prognostic markers.

Purpose of the Study:

  • To elucidate the prognostic value and functional role of SLC3A2 in glioma.
  • To investigate the association between SLC3A2 expression and the tumor microenvironment, including immune infiltration and therapeutic indicators.

Main Methods:

  • Bioinformatic analysis of public databases and clinical glioma samples.
  • Meta-analysis and Cox regression for prognostic evaluation.
  • In vitro (CCK8, colony formation, migration, invasion assays) and in vivo (orthotopic xenograft model) functional studies.
Keywords:
DisulfidptosisGliomaImmune infiltrationPrognosis

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  • Assessment of immune infiltration (CIBERSORT, ssGSEA, single-cell sequencing), TIDE, and EMT scores.

    • Main Results:

    • High SLC3A2 expression is linked to adverse clinicopathological features and poorer patient survival.
    • Upregulated SLC3A2 promotes tumor migration, invasion, and alters immune cell infiltration, particularly macrophages.
    • SLC3A2 expression correlates with immune checkpoints and TIDE, suggesting a role in immune response.
    • Knockdown of SLC3A2 reduced glioma cell proliferation, migration, invasion in vitro and suppressed tumor growth in vivo.

    Conclusions:

    • SLC3A2 serves as an independent prognostic biomarker for glioma.
    • SLC3A2 significantly influences glioma progression and the tumor immune microenvironment.
    • Targeting SLC3A2 may offer a potential therapeutic strategy for glioma.
    SLC3A2