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Published on: November 8, 2024
Risk factors for cement leakage after percutaneous vertebral augmentation for osteoporotic vertebral compression
Yu Wu1, Zelin Zhou2, Guoliang Lu1
1Department of Orthopaedics, Dongguan Hospital of Traditional Chinese Medicine, Dongguan.
Background:
Osteoporotic vertebral compression fractures (OVCF) may necessitate percutaneous vertebral augmentation (PVA), a procedure not without its risks. One notable complication is cement leakage (CL), which can cause significant distress in patients. Despite its clinical importance, there remains a paucity of meta-analyses investigating these complications and their management in the existing literature.
Material And Methods:
The authors systematically reviewed PubMed, Cochrane Library, Embase, and Web of Science databases up to February 2024 to identify studies examining CL following PVA treatment in OVCF. The authors assessed the quality of eligible cohort studies using the Newcastle-Ottawa Scale (NOS), extracted data on incidence, identified risk factors for CL, and conducting meta-analysis with Revman 5.2 software. The authors calculated odd ratios (OR) and mean differences (MD) with 95% CI applying random-effects models.
Results:
The authors identified twelve cohort studies that matched our strict inclusion criteria. These studies included a total of 2388 patients and 3392 vertebrae. CL was identified in 1132 vertebrae. Notable risk factors for CL included compromised cortical bone integrity (OR 5.00, 95% CI 3.01-8.29, P <0.00001), presence of intravertebral vacuum clefts (OR 1.68, 95% CI 1.07-2.65, P =0.03), basivertebral foramen sign (OR 1.77, 95% CI 1.09-2.89, P =0.02), and volume of cement used (MD 0.75, 95% CI 0.41-1.10, P <0.0001).
Conclusion:
The authors' findings underscore the significance of cortical bone integrity, intravertebral vacuum cleft, basivertebral foramen sign, and cement volume as principal determinants of CL risk in PVA for OVCF. These insights advocate for tailored surgical strategies to mitigate the risk of CL in this patient population.
