[Possible mechanisms of the transforming and tumorigenic effects of DNA-containing animal viruses]
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Abstract:
The literature devoted to oncogenic action of DNA-containing animal viruses and their role in the development of human neoplasias are reviewed. The regularities of persistence and expression of genetic material of DNA-containing viruses in transformed and tumor cells are comprehensively analyzed. The mechanisms of recombination of cellular and viral DNA during cell transformation as well as the specificity of integration of viral DNA into the host genome are considered. The functions and mechanisms of transforming and tumorigenic action of the products of oncogens of DNA-containing viruses of different groups are discussed. The data on the cell transformation by some DNA-containing viruses without oncogene expression are represented. The mechanism of cell transformation by DNA-containing viruses related to the activation of cellular oncogens is discussed.
Insights
This review examines how DNA-containing viruses cause cancer in humans. It analyzes viral DNA persistence, integration, and oncogene activation in tumor development.
Area of Science:
- Virology
- Oncology
- Molecular Biology
Context:
- DNA-containing animal viruses are implicated in human neoplasias.
- Understanding viral oncogenesis is crucial for cancer research.
Purpose:
- To review the oncogenic actions of DNA-containing viruses.
- To analyze viral genetic material persistence and expression in tumor cells.
- To discuss mechanisms of viral DNA integration and oncogene activation.
Summary:
- This review comprehensively analyzes the role of DNA-containing viruses in human cancer development.
- It examines viral DNA persistence, recombination with host DNA, and integration into the genome.
- Mechanisms of viral oncogene products and activation of cellular oncogenes are discussed, including transformation without direct oncogene expression.
Impact:
- Provides a comprehensive overview of viral oncogenesis.
- Highlights key mechanisms in DNA virus-induced cancer.
- Informs future research on viral cancer therapies and prevention.