Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Influencing Drug Absorption: Disease States and Pharmacology01:25

Factors Influencing Drug Absorption: Disease States and Pharmacology

489
Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
489
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

134
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
134
Cancer Prevention02:59

Cancer Prevention

6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
6.1K
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

85
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
85
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

81
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
81
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

162
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
162

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of Mendelian Randomization to Unveil Metabolic Markers in <i>Helicobacter pylori</i> Infection.

Journal of Korean medical science·2026
Same author

Efficacy and Safety of Probiotics, Prebiotics, and Synbiotics: An Umbrella Review of Systematic Reviews and Meta-Analysis of Randomized Controlled Trials.

Nutrition reviews·2026
Same author

Clonal evolution and mutational trajectories of metastatic colorectal cancer shaped by anticancer therapies.

Nature communications·2026
Same author

Advancing Gastrointestinal Cancer Risk Prediction With Patient-Centered Machine Learning: Machine Learning Modeling Study.

JMIR medical informatics·2026
Same author

Management of Responsive Lateral Pelvic Nodes After Neoadjuvant Therapy in Rectal Cancer (RESPONDER).

Annals of surgery·2026
Same author

Epidemiological Trends in Inflammatory Bowel Disease in Korea: Age-Related Shifts and Urban-Rural Disparities in a Nationwide Study, 2004-2015.

Yonsei medical journal·2026

Related Experiment Video

Updated: Jun 21, 2025

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

248

Relationship Between Aspirin Use and Site-Specific Colorectal Cancer Risk Among Individuals With Metabolic

Seokyung An1, Madhawa Gunathilake1, Jeonghee Lee1

  • 1Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea.

Journal of Korean Medical Science
|July 9, 2024
PubMed
Summary

Aspirin use is linked to a reduced risk of colorectal cancer (CRC), even in patients with hypertension (HTN) and diabetes mellitus (DM). This finding holds true for overall and site-specific CRC risks, offering valuable insights for cancer prevention strategies.

Keywords:
AspirinColorectal CancerComorbidityDiabetes MellitusHypertension

More Related Videos

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
09:01

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Published on: March 10, 2015

10.0K
Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NF&#954;B Activity and Breast Cancer Stem Cells
13:38

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Published on: January 18, 2017

12.3K

Related Experiment Videos

Last Updated: Jun 21, 2025

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

248
Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
09:01

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Published on: March 10, 2015

10.0K
Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NF&#954;B Activity and Breast Cancer Stem Cells
13:38

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Published on: January 18, 2017

12.3K

Area of Science:

  • Oncology
  • Gastroenterology
  • Epidemiology

Background:

  • The interplay between aspirin use, hypertension (HTN), and diabetes mellitus (DM) in relation to colorectal cancer (CRC) risk is not well-understood.
  • Metabolic comorbidities like HTN and DM are known risk factors for various cancers, including CRC.
  • Investigating the impact of aspirin on site-specific CRC risk in this patient population is crucial for personalized prevention.

Purpose of the Study:

  • To investigate the association between aspirin use and the risk of developing colorectal cancer (CRC).
  • To examine how this association varies across different anatomical sites of the colon and rectum.
  • To specifically assess the impact of aspirin on CRC risk in patients with co-existing hypertension and diabetes mellitus.

Main Methods:

  • A case-control study involving 1,331 CRC patients and 2,771 controls was conducted.
  • Multinomial logistic regression analyses were employed to determine odds ratios (ORs) and 95% confidence intervals (CIs).
  • The study analyzed the relationship between aspirin use, metabolic disease status (HTN, DM), and site-specific CRC risk.

Main Results:

  • Increased prevalence of hypertension (HTN) and diabetes mellitus (DM) correlated with a higher risk of overall colorectal cancer (CRC).
  • Aspirin use was significantly associated with a reduced risk of overall CRC across all analyzed anatomical sites.
  • In patients with both HTN and DM, aspirin use showed a notable reduction in the risk of overall CRC, proximal colon cancer, and rectal cancer.

Conclusions:

  • Aspirin use demonstrates a protective effect against both overall and site-specific colorectal cancer (CRC).
  • This benefit of aspirin persists even in individuals with co-existing metabolic conditions such as hypertension and diabetes mellitus.
  • The findings suggest that aspirin may be a valuable chemopreventive agent for CRC in high-risk populations with metabolic comorbidities.