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Updated: Jun 21, 2025

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Targeting Unique Ligand Binding Domain Structural Features Downregulates DKK1 in Y537S ESR1 Mutant Breast Cancer

K S Young1, G R Hancock1, E Fink1

  • 1Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, IL 50153.

Research Square
|July 9, 2024
PubMed
Summary

A novel selective estrogen receptor modulator (SERM), T6I-29, shows anti-proliferative effects in estrogen receptor alpha (ERα)-mutated breast cancer. It downregulates DKK1, a potential therapeutic target in endocrine-resistant ER+ breast cancers.

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