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Related Concept Videos

Brain Imaging01:14

Brain Imaging

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
958

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Related Experiment Video

Updated: Apr 6, 2026

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
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Consortium Profile: The Methylation, Imaging and NeuroDevelopment (MIND) Consortium.

Isabel K Schuurmans, Rosa H Mulder, Vilte Baltramonaityte

    Medrxiv : the Preprint Server for Health Sciences
    |July 9, 2024
    PubMed
    Summary

    The Methylation, Imaging and NeuroDevelopment (MIND) Consortium links peripheral DNA methylation patterns to brain development in children. This research explores gene-environment interactions and their impact on brain phenotypes.

    Keywords:
    DNA methylationEpigeneticsMRIearly lifelongitudinalmulti-cohort analysis

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    Area of Science:

    • Neuroscience
    • Genetics
    • Developmental Biology

    Background:

    • Epigenetic processes like DNA methylation are potential biomarkers for gene-environment interactions affecting brain phenotypes.
    • Current research on epigenetics and neuroimaging primarily uses cross-sectional adult data, lacking developmental insights.

    Purpose of the Study:

    • To establish the Methylation, Imaging and NeuroDevelopment (MIND) Consortium to focus on developmental neuroimaging epigenetics.
    • To promote collaborative, longitudinal research on DNA methylation and brain development from birth to adulthood.
    • To advance understanding of DNA methylation-brain dynamics across development.

    Main Methods:

    • Integrating data from 15 international cohorts with longitudinal measures of DNA methylation and neuroimaging.
    • Utilizing prospective, longitudinal pediatric study designs.
    • Pooling data for large-scale analyses (N=11,299 for DNA methylation, N=10,133 for neuroimaging).

    Main Results:

    • The MIND Consortium integrates extensive longitudinal data on DNA methylation and neuroimaging across development.
    • The study enables multi-cohort, multi-time-point analyses to investigate dynamic relationships.
    • The pooled data allows for robust investigation of peripheral epigenetics and brain structure/function.

    Conclusions:

    • The MIND Consortium bridges a critical gap in understanding peripheral DNA methylation's role in brain development.
    • This initiative will yield new insights into the dynamic interplay between epigenetics and the brain.
    • Findings are expected to inform our understanding of neurodevelopmental and psychiatric phenotypes.