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Washed microbiota transplantation improves sleep quality in patients with sleep disorder by the gut-brain axis
Hongxin He1, Manqing Li2,3, Yifan Qiu1
1Sun Yat-sen University School of Medicine, Guangzhou, China.
Background:
The clinical impact of washed microbiota transplantation (WMT) from healthy donors in sleep disorder (SD) patients is unclear. This study aimed to investigate the effect of WMT in SD patients.
Methods:
The clinical data were collected from patients with different indications receiving 1-3 courses of WMT, divided into two groups by 7 points of PSQI scale. The score of PQSI and SF-36 scale was used to assess the improvement in sleep quality and life quality among patients with sleep disorders following WMT. Finally, 16S rRNA gene amplicon sequencing was performed on fecal samples of patients with sleep disorders before and after WMT.
Results:
WMT significantly improved sleep quality in patients with sleep disorder in the short and medium term. WMT significantly improved sleep latency, sleep time and total score in the short term. WMT significantly improved sleep quality and total score in the medium term. In terms of sleep quality and sleep latency, the improvement value also increased with the increase of treatment course, and the improvement effect of multiple treatment course was better than that of single and double treatment course. In the total score, the improvement effect of double and multiple treatment was better than that of single treatment. WMT also improved quality of life in the sleep disorder group. WMT significantly improved general health, vitality, social function and mental health in the short term. WMT significantly improved role-physical, general health, vitality, and mental health in the medium term. WMT regulated the disturbed gut microbiota in patients with sleep disorders. In the normal sleep group, WMT had no effect on the decline of sleep quality in the short, medium and long term, and had an improving effect on the quality of life.
Conclusion:
WMT could significantly improve sleep quality and life quality in patients with sleep disorders with no adverse events. The improvement in sleep quality resulting from WMT could lead to an overall enhancement in life quality. WMT could be a potentially effective treatment for patients with sleep disorders by regulating the gut microbiota.
Insights
Washed microbiota transplantation (WMT) significantly improves sleep quality and life quality in patients with sleep disorders. This gut microbiota-regulating therapy shows promise as an effective treatment with no adverse events.
Area of Science:
- Microbiology
- Gastroenterology
- Sleep Medicine
Background:
- The clinical impact of washed microbiota transplantation (WMT) in patients with sleep disorders (SD) remains unclear.
- WMT involves transplanting gut microbiota from healthy donors to patients with SD.
Purpose of the Study:
- To investigate the effect of WMT on sleep quality and life quality in patients with sleep disorders.
- To assess the impact of WMT on gut microbiota composition in SD patients.
Main Methods:
- Patients with sleep disorders received 1-3 courses of WMT.
- Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI).
- Life quality was evaluated using the SF-36 scale, and gut microbiota was analyzed via 16S rRNA gene sequencing.
Main Results:
- WMT significantly improved sleep quality, including sleep latency and duration, in the short and medium term.
- Multiple WMT courses showed better improvement than single or double courses.
- WMT enhanced life quality, improving general health, vitality, social function, and mental health, and modulated gut microbiota.
Conclusions:
- WMT is a safe and effective treatment for improving sleep and life quality in patients with sleep disorders.
- The therapeutic effects of WMT are linked to the regulation of gut microbiota.
- WMT offers a promising therapeutic strategy for managing sleep disorders.
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