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Updated: Jun 21, 2025

Measuring Caenorhabditis elegans Life Span in 96 Well Microtiter Plates
Published on: March 18, 2011
Multiple Targets, One Goal: Compounding life-extending effects through Polypharmacology
K Avchaciov1, K J Clay2, K Denisov1,2
1Gero PTE, 60 Paya Lebar Road # 05-40B, Paya Lebar Square, 409051, Singapore.
Abstract:
Analysis of lifespan-extending compounds suggested the most effective geroprotectors target multiple biogenic amine receptors. To test this hypothesis, we used graph neural networks to predict such polypharmacological compounds and evaluated them in C. elegans. Over 70% of the selected compounds extended lifespan, with effect sizes in the top 5% compared to the DrugAge database. This reveals that rationally designing polypharmacological compounds enables the design of geroprotectors with exceptional efficacy.
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