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Updated: Jun 21, 2025
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Defining the Program of Maternal mRNA Translation during In vitro Maturation using a Single Oocyte Reporter Assay
Published on: June 16, 2021
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Influence of Long Non-Coding RNAs on Human Oocyte Development
Leitong Wang1, Baoshan Li1, Dongkai Cheng1
1Embryo Laboratory, Jinghua Hospital of Shenyang, Shenyang, Liaoning Province, 110000, People's Republic of China.
Pharmacogenomics and Personalized Medicine
|July 9, 2024
Summary
Long non-coding RNAs (lncRNAs) are crucial for human oocyte and embryo development. Their abnormal expression is linked to infertility, impacting cell processes and developmental quality.
Area of Science:
- Reproductive biology
- Molecular genetics
- Developmental biology
Background:
- Long non-coding RNAs (lncRNAs) play critical roles in human development and disease.
- lncRNAs are present in oocytes and early embryos, with dynamic expression changes post-embryonic genome activation.
- Altered lncRNA expression is observed in infertility patients, affecting key cellular functions.
Purpose of the Study:
- To provide a comprehensive overview of lncRNA influence on human oocyte development.
- To explore the involvement of lncRNAs in infertility-related diseases.
Main Methods:
- Literature review of recent research findings on lncRNAs in human reproduction.
- Analysis of studies linking lncRNA expression to oocyte and embryo quality.
- Examination of lncRNA roles in cell proliferation, apoptosis, and maturation.
Main Results:
- lncRNAs are dynamically expressed during early human embryonic development.
- Abnormal lncRNA expression in follicular fluid, granulosa cells, and oocytes is associated with infertility.
- Specific lncRNAs in cumulus cells correlate with oocyte and early embryo quality.
Conclusions:
- lncRNAs significantly influence human oocyte developmental processes.
- Dysregulated lncRNAs are implicated in the pathogenesis of certain infertility conditions.
- Understanding lncRNA roles offers potential insights into diagnosing and treating infertility.
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