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Antimicrobial gel with silver vanadate and silver nanoparticles: antifungal and physicochemical evaluation
João Marcos Carvalho-Silva1, Ana Beatriz Vilela Teixeira1, Marco Antônio Schiavon2
1Department of Dental Materials & Prosthesis, Ribeirão Preto School of Dentistry, University of São Paulo (USP), Ribeirão Preto, Brazil.
Abstract:
Aim: To develop a β-AgVO3 gel and evaluate its physicochemical stability and antifungal activity against Candida albicans.Materials & methods: The gel was prepared from the minimum inhibitory concentration (MIC) of β-AgVO3. The physicochemical stability was evaluated by centrifugation, accelerated stability (AS), storage (St), pH, syringability, viscosity and spreadability tests and antifungal activity by the agar diffusion.Results: The MIC was 62.5 μg/ml. After centrifugation, AS and St gels showed physicochemical stability. Lower viscosity and higher spreadability were observed for the higher β-AgVO3 concentration and the minimum force for extrusion was similar for all groups. Antifungal effect was observed only for the β-AgVO3 gel with 20xMIC.Conclusion: The β-AgVO3 gel showed physicochemical stability and antifungal activity.
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