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Updated: Aug 19, 2026

Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
Current thinking on the role of surgery in gastroesophageal reflux
Insights
Gastroesophageal reflux in children often resolves naturally. However, severe cases may require surgery when medical treatments fail, addressing complications like lung infections and apnea.
Area of Science:
- Pediatric Gastroenterology
- Pediatric Surgery
Background:
- Gastroesophageal reflux is a common condition in infants and children.
- While often benign, reflux can lead to severe complications in a subset of patients.
Purpose of the Study:
- To outline the indications for surgical intervention in pediatric gastroesophageal reflux.
- To discuss the surgical options and their associated outcomes.
Main Methods:
- Review of established surgical indications for refractory gastroesophageal reflux in pediatric patients.
- Discussion of surgical techniques, including fundoplication, and their respective risks and benefits.
Main Results:
- Surgical intervention is considered when medical management fails to resolve complications such as recurrent pulmonary infections, obstructive apnea, nutritional wasting, or esophageal injury.
- Complete fundoplication offers robust reflux control but carries a higher risk of complications.
Conclusions:
- Surgical management of pediatric gastroesophageal reflux is reserved for specific, severe cases with established cause-effect relationships.
- The choice of surgical procedure should be tailored to surgeon expertise, balancing efficacy with potential side effects.
Abstract:
Gastroesophageal reflux is common in infants and children. In most cases it causes little more than inconvenience and remits spontaneously with time and maturation. A small and select group of refluxing children, however, will develop complications of reflux severe enough to justify operative control when medical treatment fails. Recurrent pulmonary infections, obstructive apnea, nutritional wasting, and progressive inflammatory injury to the esophagus all qualify as surgical indications, provided a reasonable cause-effect relationship with reflux can be established. The procedure of choice depends very much upon the skill and experience of the surgeon. The complete fundoplication seems to offer more complete control of reflux, but it has the potential for more frequent and more complicated side-effects.
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