Calibration by Proxy

Area of Science:

• Analytical Chemistry
• Spectroscopy

Background:

• Matrix-matched calibration is crucial for accurate elemental analysis.
• Traditional methods can be complex and time-consuming.

Purpose of the Study:

• To introduce and validate Calibration by Proxy (CbPx) as a simplified calibration method.
• To demonstrate the efficacy of CbPx in complex sample matrices.

Main Methods:

• Developed a two-solution calibration approach using internal standards.
• Applied CbPx to inductively coupled plasma optical emission spectrometry (ICP-OES).
• Validated the method using certified reference materials and vitamin tablets.

Main Results:

• CbPx achieved high accuracy with analyte recoveries ranging from 89% to 106%.
• Demonstrated excellent precision with relative standard deviations around 1%.
• Established a recommended working range for the CbPx method.

Conclusions:

• Calibration by Proxy offers a robust and efficient alternative for elemental analysis.
• The method simplifies sample preparation while maintaining high accuracy and precision.
• CbPx is suitable for analyzing diverse samples, including pharmaceutical products.