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Related Concept Videos

Instrument Calibration01:12

Instrument Calibration

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Instrument calibration is essential for ensuring that instruments produce accurate and consistent results. It is vital in manufacturing, healthcare, testing laboratories, and scientific research. Calibration processes are specific to each instrument and help enhance data accuracy. Each instrument has a unique calibration process tailored to its design and function to improve data accuracy.
Analytical Balance Calibration
An analytical balance measures mass and requires regular calibration to...
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Calibration Curves: Linear Least Squares01:20

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A calibration curve is a plot of the instrument's response against a series of known concentrations of a substance. This curve is used to set the instrument response levels, using the substance and its concentrations as standards. Alternatively, or additionally, an equation is fitted to the calibration curve plot and subsequently used to calculate the unknown concentrations of other samples reliably.
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Glassware Calibration01:11

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Accurate calibration of glassware, such as volumetric flasks, pipettes, and burettes, is essential to ensure accurate measurements in the analytical laboratory. Calibration helps maintain consistency across measurements and prevents errors arising from inaccurate volumes.
Volumetric flasks: Volumetric flasks are designed to prepare aqueous solutions of precise volumes accurately with a calibration line on the neck. To calibrate a volumetric flask, it is important to fill it with distilled...
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Distance Corrections01:15

Distance Corrections

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To achieve precise distance measurements, especially in surveying and construction, certain corrections must be applied to account for potential sources of error like the standardization errors, temperature variations, and slope adjustments.Standardization error emerges when measurement equipment undergoes changes, such as wear, repairs, or weather impacts. To address this, surveyors compare the equipment’s readings to a standard. This process identifies any deviation that might lead to...
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Blank Solutions00:56

Blank Solutions

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A blank solution is a solution that does not contain the analyte, or the substance of interest being tested or measured. It is typically prepared using the same reagents and procedure as the sample solution but without adding the analyte. The primary purpose of preparing a blank solution is to account for any background interference or contamination that may affect the accuracy and reliability of the analytical method.
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The Stereotype Content Model (SCM) was first proposed by Susan Fiske and her colleagues (Fiske, Cuddy, Glick & Xu, 2002; see also Fiske, 2012 and Fiske, 2017). The SCM specifies that when someone encounters a new group, they will stereotype them based on two metrics: warmth—or that group’s perceived intent, and how likely they are to provide help or inflict harm—and competence—or their ability to carry out that objective. Depending on the warmth-competence...
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Split Point Analysis and Uncertainty Quantification of Thermal-Optical Organic/Elemental Carbon Measurements
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Calibration by Proxy.

Willis B Jones1, Abigail J Crossman1, Bradley T Jones2

  • 1Department of Chemistry and Biochemistry, University of North Florida, Jacksonville, Florida 32224, United States.

Analytical Chemistry
|July 9, 2024
PubMed
Summary
This summary is machine-generated.

Calibration by Proxy (CbPx) is a novel matrix-matched calibration method using internal standards. This technique simplifies sample preparation and accurately quantifies analytes in complex matrices like vitamin tablets.

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Area of Science:

  • Analytical Chemistry
  • Spectroscopy

Background:

  • Matrix-matched calibration is crucial for accurate elemental analysis.
  • Traditional methods can be complex and time-consuming.

Purpose of the Study:

  • To introduce and validate Calibration by Proxy (CbPx) as a simplified calibration method.
  • To demonstrate the efficacy of CbPx in complex sample matrices.

Main Methods:

  • Developed a two-solution calibration approach using internal standards.
  • Applied CbPx to inductively coupled plasma optical emission spectrometry (ICP-OES).
  • Validated the method using certified reference materials and vitamin tablets.

Main Results:

  • CbPx achieved high accuracy with analyte recoveries ranging from 89% to 106%.
  • Demonstrated excellent precision with relative standard deviations around 1%.
  • Established a recommended working range for the CbPx method.

Conclusions:

  • Calibration by Proxy offers a robust and efficient alternative for elemental analysis.
  • The method simplifies sample preparation while maintaining high accuracy and precision.
  • CbPx is suitable for analyzing diverse samples, including pharmaceutical products.