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Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
Published on: July 25, 2013
A Closer Look at Type I Left-Handed β-Helices Provides a Better Understanding in Their Sequence-Structure
Maxime Naudé1, Peter Faller1, Vincent Lebrun1
1Institute of Chemistry of Strasbourg (UMR 7177), University of Strasbourg-CNRS, Strasbourg, France.
Abstract:
Understanding the sequence-structure relationship in protein is of fundamental interest, but has practical applications such as the rational design of peptides and proteins. This relationship in the Type I left-handed β-helix containing proteins is updated and revisited in this study. Analyzing the available experimental structures in the Protein Data Bank, we could describe, further in detail, the structural features that are important for the stability of this fold, as well as its nucleation and termination. This study is meant to complete previous work, as it provides a separate analysis of the N-terminal and C-terminal rungs of the helix. Particular sequence motifs of these rungs are described along with the structural element they form.
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