Related Experiment Video
Updated: Jun 21, 2025

Author Spotlight: Advancing Thymic Epithelial Cells and T-Cell Research with Human Thymic Organoids
Published on: October 4, 2024
Generation and repair of thymic epithelial cells
Graham Anderson1, Emilie J Cosway1, Kieran D James1
1Institute for Immunology and Immunotherapy, University of Birmingham , Birmingham, UK.
None:
In the vertebrate immune system, thymus stromal microenvironments support the generation of αβT cells from immature thymocytes. Thymic epithelial cells are of particular importance, and the generation of cortical and medullary epithelial lineages from progenitor stages controls the initiation and maintenance of thymus function. Here, we discuss the developmental pathways that regulate thymic epithelial cell diversity during both the embryonic and postnatal periods. We also examine how thymus microenvironments respond to injury, with particular focus on mechanisms that ensure regeneration of thymic epithelial cells for the restoration of thymus function.
More Related Videos
09:41Preparation of Single-Cell Suspension of Mouse Thymic Epithelial Cells and Staining of Intracellular Molecules for Flow Cytometric AnalysisMechanisms
Published on: July 26, 2024
08:56Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays
Published on: June 9, 2015
Related Concept Videos
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cells of the Adaptive Immune Response
Renewal of Skin Epidermal Stem Cells
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
Overview of Regeneration and Repair
Regeneration
All animals have varying degrees of...
Tissue Renewal without Stem Cells
However, failure of such a system...