Long-term consequences of positive surgical margin after partial nephrectomy for renal cell carcinoma: multi-institutional analysis
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Positive surgical margins (PSM) after nephrectomy increase recurrence rates but do not significantly impact overall survival in kidney cancer patients, even after accounting for biases.
Area Of Science
- Urology
- Oncology
- Nephrology
Background
- Positive surgical margins (PSM) are a concern after nephrectomy (PN) for localized renal tumors.
- Understanding the long-term impact of PSM on recurrence and survival is crucial for patient management.
Purpose Of The Study
- To determine the very long-term impact of positive surgical margins (PSM) after nephrectomy (PN) on recurrence in a contemporary cohort.
- To assess disease-free survival (DFS) and overall survival (OS) in patients with and without PSM.
Main Methods
- Retrospective analysis of 1115 patients who underwent PN for localized renal tumors.
- Stratification based on the presence or absence of PSM.
- Kaplan-Meier analysis for DFS and OS, with log-rank tests for comparisons. Propensity score analysis was used for sensitivity analyses.
Main Results
- The incidence of PSM was 5.4%. Recurrence rates were significantly higher in the PSM group (13%) compared to the no-SM group (7%) (p=0.05).
- Disease-free survival (DFS) was significantly reduced in the PSM group (p=0.004), especially for clear cell renal cell carcinoma.
- While initial analysis showed lower OS in the PSM group, propensity score analysis revealed no significant difference in OS (p=0.49) but confirmed reduced DFS (p=0.05).
Conclusions
- Positive surgical margins after nephrectomy are associated with increased recurrence rates.
- Despite increased recurrence, PSM did not significantly impact overall survival after accounting for potential biases.
- These findings highlight the importance of margin status in predicting recurrence after nephrectomy for renal tumors.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.