Related Experiment Video

Updated: Jun 21, 2025

A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery
07:20

A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery

Published on: February 28, 2020

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Functional and clinical roles of stromal PDGF receptors in tumor biology

Carina Strell1,2, Elisabet Rodríguez-Tomàs3, Arne Östman4,5

  • 1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

Cancer Metastasis Reviews
|July 9, 2024
PubMed

Insights

Platelet-derived growth factor receptors (PDGFRs) are crucial in cancer development and progression. Targeting PDGFRs in the tumor microenvironment offers new therapeutic strategies and potential biomarker applications.

Area of Science:

  • Oncology
  • Cell Biology
  • Molecular Biology

Background:

  • Platelet-derived growth factor receptors (PDGFRs) regulate mesenchymal cells, crucial for tissue development and physiological functions.
  • PDGF signaling pathways are implicated in the pathogenesis of various human cancers.
  • Mesenchymal cells within the tumor microenvironment play a significant role in cancer progression.

Purpose of the Study:

  • To review the biological mechanisms and clinical relevance of PDGFRs in mesenchymal cells of the tumor microenvironment.
  • To explore the role of PDGF signaling in tumor growth, metastasis, and drug efficacy.
  • To discuss the potential of PDGFRs as biomarkers for prognosis and treatment response.

Main Methods:

  • Review of experimental findings and correlative studies on PDGFRs in cancer.
  • Analysis of biological mechanisms underlying PDGF signaling in the tumor microenvironment.
  • Examination of clinical relevance and patient tissue sample data.

Main Results:

  • PDGF system critically regulates tumor growth, metastasis, and drug efficacy.
  • Inter-patient variability in stromal PDGFR expression correlates with prognosis and treatment responses.
  • PDGFRs present unexploited targeting opportunities in cancer therapy.

Conclusions:

  • The PDGF system is a key regulator in the tumor microenvironment, impacting tumor progression and treatment outcomes.
  • Stratified therapeutic approaches and PDGFR-based biomarkers are warranted for clinical utility.
  • PDGFRs may serve as biomarkers even in treatments not directly targeting these receptors.
Keywords:
BiomarkerCancerFibroblastsPDGFPDGF receptorsPericytesPrognosisResponse-predictionTumor microenvironmentTumor stroma

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