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Heterocyclic Hemipiperazines: Multistimuli-Responsive Switches and Sensors for Zinc or Cadmium Ions
Valentin Schäfer1, Zbigniew L Pianowski2,1
1Institute of Organic Chemistry IOC KIT, Karlsruhe Institute of Technology, Kaiserstrasse 12, 76131, Karlsruhe, Germany.
Abstract:
Advance in the design of molecular photoswitches - adapters that convert light into changes at molecular level - opens up exciting possibilities in preparing smart polymers, drugs photoactivated inside humans, or light-fueled nanomachines that might in the future operate in our bloodstream. Hemipiperazines are recently reported biocompatible molecular photoswitches based on cyclic dipeptides. Here we report a multistimuli-responsive hemipiperazine-based switch that reacts on light, solvents, acidity, or metal ions. Its photoequilibration is controlled by the intramolecular hydrogen bonding pattern. The compound can be used as a mid-nanomolar photoswitchable fluorescent sensor for zinc and cadmium ions, applicable to monitor environmental pollution in real time.
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