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Biomolecule-grafted GO enhanced the mechanical and biological properties of 3D printed PLA scaffolds with TPMS porous structure

  • 0Department of Research, Guangxi Medical University Cancer Hospital, Nanning, 530021, China.
Journal of the Mechanical Behavior of Biomedical Materials +

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July 9, 2024

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July 9, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

L-lysine modification of graphene oxide (GO) improved its dispersion and bonding in polylactic acid (PLA) scaffolds. This enhanced mechanical properties and biocompatibility for bone tissue engineering applications.

Area Of Science

  • Biomaterials Science
  • Polymer Chemistry
  • Nanotechnology

Background

  • Graphene oxide (GO) offers excellent mechanical properties but faces challenges in polymer composites due to poor dispersion and interfacial bonding.
  • Traditional surface modification agents for GO-polymer composites can raise biocompatibility concerns in biomedical applications.

Purpose Of The Study

  • To investigate the use of the biomolecule L-lysine for surface modification of GO to enhance its integration with polylactic acid (PLA).
  • To develop biocompatible PLA/L-lysine-modified GO (PLA/L-GO) composite bone scaffolds with improved mechanical and biological properties.

Main Methods

  • L-lysine was grafted onto graphene oxide (GO) via reactions between carboxyl and amine groups.
  • PLA/L-GO composite scaffolds with triply periodic minimal surface (TPMS) structures were fabricated using fused deposition modeling (FDM).
  • Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and mechanical testing were employed for characterization.

Main Results

  • Successful grafting of L-lysine onto GO was confirmed by FTIR.
  • L-lysine modification improved GO dispersion and interfacial adhesion within the PLA matrix, as evidenced by SEM.
  • The PLA/0.1L-GO scaffold demonstrated significantly enhanced compressive strength (13.2 MPa) and elastic modulus (226.8 MPa) compared to PLA/0.1GO.
  • PLA/L-GO scaffolds exhibited superior biomineralization capacity and cellular response.

Conclusions

  • L-lysine serves as an effective and biocompatible modifier to improve GO dispersion and interfacial bonding in PLA composites.
  • The developed PLA/L-GO composite scaffolds show promising potential for bone tissue engineering applications due to enhanced mechanical and biological performance.
  • Biomolecules offer a viable alternative to traditional modifiers for advanced polymer/inorganic composite biomaterials.

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