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Updated: Jun 21, 2025

Generation of Induced Pluripotent Stem Cells from Human Melanoma Tumor-infiltrating Lymphocytes
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Generation of immune cells from induced pluripotent stem cells (iPSCs): Their potential for adoptive cell therapy

Mahsa Gheitasi1, Sepeher Safdel1, Sananda Kumar Patra2

  • 1Department of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Human Immunology
|July 9, 2024
PubMed

Advances in human stem cell technologies enable induced pluripotent stem cells (iPSCs) to be explored as potent candidates for treating various diseases, such as malignancies, autoimmunity, immunodeficiencies, and allergic reactions. iPSCs with infinite self-renewal ability can be derived from different types of somatic cells without the ethical issues associated with embryonic stem cells. To date, numerous cell types, including various immune cell subsets [CD4+ and CD8+ T cells, gamma delta T (γδ T) cells, regulatory T cells, dendritic cells, natural killer cells, macrophages, and neutrophils] have successfully been generated from iPSCs paving the way for effective adoptive cell transfer therapy, drug development, and disease modeling. Herein, we review various iPSC-derived immune cells and their possible application in immunotherapy.

Keywords:
ImmunologyImmunotherapyInduced pluripotent stem cellsLeukocytes

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