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Ataxia-Telangiectasia Mutated (ATM) gene signaling pathways in human cancers and their therapeutic implications

Varsha Varadhan1, Monica Shri Manikandan1, Akshaya Nagarajan1

  • 1Department of Biotechnology, Dr. M.G.R Educational and Research Institute, Chennai 600095, India.

Pathology, Research and Practice
|July 9, 2024
PubMed

Insights

The mutated Ataxia-telangiectasia gene (ATM) plays a key role in cancer development and treatment resistance. Targeting the ATM pathway offers promising strategies for personalized cancer therapies and improved patient outcomes.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Cancer is a complex disease with multifactorial causes, including genetic alterations.
  • Individual susceptibility to therapies and drug resistance present significant challenges in cancer treatment.
  • The Ataxia-telangiectasia gene (ATM) is crucial for maintaining genomic stability and is implicated in various cancers.

Purpose of the Study:

  • To review the multifaceted role of the Ataxia-telangiectasia gene (ATM) in human cancers.
  • To highlight the impact of ATM gene mutations on DNA repair pathways and therapeutic responses.
  • To explore the potential of targeting the ATM pathway for improved cancer treatment strategies.

Main Methods:

  • Literature review focusing on the genetic basis of cancer.
  • Analysis of the role of the Ataxia-telangiectasia gene (ATM) in oncogenesis and progression.
  • Examination of ATM gene's influence on therapeutic responses in various cancer types.

Main Results:

  • Mutations in the Ataxia-telangiectasia gene (ATM) are linked to oncogenesis, cancer progression, and metastasis.
  • ATM gene status influences patient susceptibility to therapeutic drugs and the development of drug resistance.
  • Targeting the ATM pathway, particularly in conjunction with DNA damage response pathways, shows promise for enhancing treatment efficacy.

Conclusions:

  • Understanding the genetic role of ATM is crucial for the diagnosis, management, and personalized treatment of cancers.
  • ATM mutations significantly impact DNA repair mechanisms and influence treatment outcomes in breast, lung, prostate, and gastric cancers.
  • Targeting ATM pathways represents a promising avenue for developing novel therapeutic interventions and improving patient prognosis.
Keywords:
ATM geneAtaxia-Telangiectasia geneHuman cancersSignaling pathwaysTherapeutic implications

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