Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Leaky Scanning02:28

Leaky Scanning

5.1K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanisms and Performance of a Copper-Modified Lead Dioxide Anode for Electrochemical Cephalexin Removal: Roles of Hydroxyl Radicals and Operational Parameters.

ChemistryOpen·2026
Same author

Histological transformation into pulmonary sarcomatoid carcinoma from lung adenosquamous carcinoma after radical resection of EGFR gene Exon-21 L858R mutation: a case report and literature review.

Frontiers in oncology·2026
Same author

Development of high-affinity polyclonal antibodies against chicken CKAP4 and its application in infectious bursal disease.

International journal of biological macromolecules·2026
Same author

A Bioinspired Flexible Pressure Sensor with High Linearity Based on a Three-Dimensional Porous Structure.

Biomimetics (Basel, Switzerland)·2026
Same author

Mapping the neuroimaging landscape of inflammatory bowel disease: a bibliometric analysis and systematic scoping review.

Frontiers in neuroscience·2026
Same author

A stage-based framework for closed-loop recycling of polymeric composite membranes.

Science advances·2026

Related Experiment Video

Updated: Jun 21, 2025

An Ex Vivo Chicken Primary Bursal-cell Culture Model to Study Infectious Bursal Disease Virus Pathogenesis
07:26

An Ex Vivo Chicken Primary Bursal-cell Culture Model to Study Infectious Bursal Disease Virus Pathogenesis

Published on: October 4, 2018

9.0K

Chicken PRMT3 facilitates IBDV replication.

Zhixuan Xiong1, Jingjing Cao2, Mengchen Xiu3

  • 1Department of Veterinary Preventive Medicine, College of Animal Science and Technology, Jiangxi Agricultural University, Qingshan Lake, Nanchang, 330045, PR China; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, 430070, PR China.

Poultry Science
|July 9, 2024
PubMed
Summary

Chicken protein arginine methyltransferases (PRMTs) inhibit interferon production, aiding viral replication. PRMT3 specifically supports infectious bursal disease virus (IBDV) replication by suppressing interferon signaling, offering new therapeutic targets.

Keywords:
IBDVPRMT3chickenfacilitateinterferon-β

More Related Videos

Generating Recombinant Avian Herpesvirus Vectors with CRISPR/Cas9 Gene Editing
12:21

Generating Recombinant Avian Herpesvirus Vectors with CRISPR/Cas9 Gene Editing

Published on: January 7, 2019

13.3K
Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells
10:22

Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells

Published on: November 12, 2015

8.7K

Related Experiment Videos

Last Updated: Jun 21, 2025

An Ex Vivo Chicken Primary Bursal-cell Culture Model to Study Infectious Bursal Disease Virus Pathogenesis
07:26

An Ex Vivo Chicken Primary Bursal-cell Culture Model to Study Infectious Bursal Disease Virus Pathogenesis

Published on: October 4, 2018

9.0K
Generating Recombinant Avian Herpesvirus Vectors with CRISPR/Cas9 Gene Editing
12:21

Generating Recombinant Avian Herpesvirus Vectors with CRISPR/Cas9 Gene Editing

Published on: January 7, 2019

13.3K
Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells
10:22

Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells

Published on: November 12, 2015

8.7K

Area of Science:

  • Immunology
  • Virology
  • Molecular Biology

Background:

  • Protein arginine methyltransferases (PRMTs) are crucial in mammalian signaling pathways, including antiviral responses.
  • The specific roles of chicken PRMTs in interferon production and viral interactions are not well understood.

Purpose of the Study:

  • To investigate the function of chicken PRMTs in interferon production and their role in infectious bursal disease virus (IBDV) replication.
  • To elucidate the involvement of PRMTs in the MDA5-MAVS-TBK1 signaling pathway.

Main Methods:

  • Investigated chicken PRMTs' function in interferon production upon dsRNA or MDA5 stimulation.
  • Analyzed PRMT colocalization with IBDV viral protein VP3.
  • Examined PRMT3 expression, its role in IBDV replication using ectopic expression and SGC-707 inhibition, and the effects of PRMT3 silencing.

Main Results:

  • Chicken PRMTs inhibit interferon production induced by dsRNA or MDA5.
  • PRMTs participate at different stages of the MDA5-MAVS-TBK1 interferon induction pathway.
  • PRMT3 is upregulated during IBDV infection, colocalizes with VP3, and supports IBDV replication.
  • PRMT3 silencing enhances interferon production and inhibits IBDV replication.

Conclusions:

  • Chicken PRMTs, particularly PRMT3, suppress interferon signaling to promote IBDV replication.
  • PRMT3 is a key factor in IBDV pathogenesis, representing a potential target for antiviral strategies.