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Application of Delayed Repeated Enema With Sedation in Pediatric Intussusception: A Single Center Retrospective Study
Qiulong Shen1, Dayong Wang1, Tingting Liu1
1Department of Emergency Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 Nanlishi St, Xicheng District, Beijing 100045 China.
Insights
Delayed repeated air enema (DRE) with sedation is a safe and feasible method to improve pediatric intussusception reduction success rates. Left-sided intussusception is a key risk factor for DRE failure.
Area of Science:
- Pediatric Gastroenterology
- Interventional Radiology
- Surgical Outcomes
Background:
- Intussusception is a common pediatric surgical emergency.
- Air enema reduction is a primary treatment modality.
- Sedation during air enema may improve outcomes.
Purpose of the Study:
- To evaluate the clinical application and effectiveness of delayed repeated air enema (DRE) with sedation for pediatric intussusception.
- To identify risk factors associated with DRE failure.
Main Methods:
- Retrospective analysis of 211 pediatric intussusception cases treated with DRE with sedation.
- Comparison of patient demographics, clinical features, and surgical data between success and failure groups.
- Logistic regression analysis to determine independent risk factors for DRE failure.
Main Results:
- The success rate of DRE with sedation was 76.8% (162/211).
- Overall air enema reduction success rate was 97.8%.
- Factors associated with DRE failure included age ≤1 year, bloody stools, and left-sided intussusception; left-sided intussusception was an independent risk factor (OR=10.1).
Conclusions:
- DRE with sedation is feasible and safe for treating pediatric intussusception.
- This method enhances the overall success rate of air enema reduction.
- Left-sided intussusception is a significant independent predictor of enema failure.
Objective:
This study aimed to evaluate the clinical application of delayed repeated air enema (DRE) with sedation in pediatric intussusception.
Method:
We retrospectively assessed cases of idiopathic intussusception treated with air enema reduction at the emergency department of Beijing Children's Hospital affiliated to Capital Medical University from January 2016 to August 2019. The included cases were assigned to the success or failure groups based on the outcomes of DRE with sedation. General patient information, clinical manifestations, test results, and surgical conditions were collected for comparative analysis.
Results:
A total of 3052 cases were initially diagnosed with intussusception and underwent air enema reduction. Ultimately, 211 cases were included, with 162 in the success group and 49 in the failure group. The success rate of DRE with sedation was 76.8% (162/211), with an overall reduction success rate of 97.8% (2984/3052). Univariate logistic regression analysis showed that patients in the failure group had a significantly higher proportion of patients with age ≤1 year, bloody stools, and left-sided intussusception before DRE compared to the success group (OR = 2.3, 95%CI: 1.1∼4.6, P = 0.023; OR = 3.4, 95%CI: 1.6∼7.2, P = 0.002 and OR = 12.6, 95%CI: 4.6∼34.6, P < 0.001). Multiple logistic regression analysis based on these three factors revealed that the risk of DRE failure was 10.1 times higher in cases with the left-sided intussusception before DRE.
Conclusions:
DRE with sedation can improve the overall enema reduction success rate for intussusception and has good feasibility and safety profiles. Left-sided intussusception before DRE is an independent risk factor for enema failure.
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